Interstrand disulfide crosslinking of DNA bases supports a double nucleotide unpairing mechanism for flap endonucleases.
نویسندگان
چکیده
Flap endonucleases (FENs) are proposed to select their target phosphate diester by unpairing the two terminal nucleotides of duplex. Interstrand disulfide crosslinks, introduced by oxidation of thiouracil and thioguanine bases, abolished the specificity of human FEN1 for hydrolysis one nucleotide into the 5'-duplex.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 71 شماره
صفحات -
تاریخ انتشار 2012